N=Me – Fatty Acid composition and effects on biomarkers

//N=Me – Fatty Acid composition and effects on biomarkers
N=Me – Fatty Acid composition and effects on biomarkers 2017-12-08T11:32:52+00:00


My previous experiment where all of my calories for 4 weeks came via Keto Chow brought out some interesting data in my 3rd week. That week I changed my fat source from heavy cream over to avocado oil, this resulted in some remarkable blood tests. A question arises as to whether my elevated Triglycerides, lowered LDL, Lowered HDL and more are a result of the reduced carbohydrates (under 2g net a day average), or the composition of the fats I was eating: Saturated vs. Monounsaturated, vs. Polyunsaturated. This experiment intends to answer that question by isolating the fatty acids as the only variable.

At the same time, I’ll be putting another popular theory to the test: CICO or “Calories In = Calories Out”. The theory is that a calorie, is a calorie, is a calorie; and that the kind of calories makes no difference, only the quantity of calories. People get overweight because they eat more calories than they burn, which is the same as saying people get wealthy because they spend less money than they earn – both are technically true but don’t tell you the why just the what. Even die-hard CICO believers will balk at giving kids cookies for dinner (which is funny, I thought a calorie was a calorie?). Regardless, I will be able to definitively isolate the number of calories as a fixed variable with the only change being the type of calories, either from different kinds of fats, or from pure glucose. If the type of food is irrelevant, I should see no change in weight loss, blood sugar, energy, or other results. My hypothesis is that during the week I’m replacing fat with dextrose I will:

  • Gain weight, initially from glycogen (water weight) but it will likely go beyond that.
  • Feel like crap with little energy, despite an overabundance of glucose in my system.
  • My fasting insulin will go through the roof.
  • My A1c will go up.
  • My Blood sugar will also go way up – I’ll be measuring this daily, along with ketones, throughout the experiment.

Test Methodology

Each week I will be testing a different fat/calorie source. Each will be tuned for 2000 calories a day total caloric intake.

  • Week 1: Oil high in PUFAs (Grape Seed Oil)
  • Week 2: Heavy Cream – high in Saturated Fatty Acids but does not contain Medium Chain Triglycerides which could confound the results.
  • Week 3: Oil high in MUFAs (Macadamia Nut Oil)
  • Week 4: Oil High in Saturated Fatty Acids (Liquid Coconut Oil – this is also high in Medium Chain Triglycerides which are metabolized directly into ketones)
  • Week 5: Dextrose – contains no fats, pure carbohydrates

I will be taking fish pills all 5 weeks, including week 5 where I will be only consuming a meager 4g of fats a day, most of that from the fish pills. This will be the embodiment of conventional recommendations of high carb low fat. I expect to feel like crap and to gain weight using the same calorie amount as the previous weeks.

Throughout the test I will be taking blood tests, tracking my weight, blood ketones, and glucose.

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